Lumina
ProteinGym Hard leaderboard
1 ranked models · higher is better · labels show rank and score
View accessible chart data
| Model | Rank | Provider | Score |
|---|---|---|---|
| Claude Opus 5 | #1 | Anthropic | 47.7% |
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Knowledge · Benchmark profile
Predicts mutation effects by ranking mutant protein sequences against wild type and comparing against laboratory measurements.
Data verified 27 Jul 2026 · Methodology 1.7.0
Visual analysis
Switch between model placement, score distribution and descriptive provider averages. Every view uses the same sourced leaderboard.
1 ranked models · higher is better · labels show rank and score
| Model | Rank | Provider | Score |
|---|---|---|---|
| Claude Opus 5 | #1 | Anthropic | 47.7% |
One best score per model · higher is better
| Rank | Model | Provider | License | Evidence use | Score |
|---|---|---|---|---|---|
| #1 | Claude Opus 5 claude-opus-5 | Anthropic | closed | Estimated reference | 47.7% |
About ProteinGym Hard
Predicts mutation effects by ranking mutant protein sequences against wild type and comparing against laboratory measurements. Results stay tied to the exact model variant and evaluation system. Multiple systems for the same model use the best published score on this page; overall Lumina scoring uses the median of ranking-eligible rows.
Open benchmark source ↗FAQ
Predicts mutation effects by ranking mutant protein sequences against wild type and comparing against laboratory measurements.
Claude Opus 5 by Anthropic currently leads with 47.7%.
1 model in the LuminaBench cohort have a qualifying score on this benchmark.
No. This benchmark is display-only and does not enter the overall Lumina composite.
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